Research in my laboratory is focused to better understand how metabolic reprogramming regulates platelet and leukocyte function and whether targeting enzymes involved in aerobic glycolysis can inhibit thrombo-inflammation. If successful, this could be developed as a therapeutic strategy toward better management of patients at high risk for acute coronary events and stroke. We utilize state-of-the-art imaging techniques like intravital microscopy, laser-speckle imaging and magnetic resonance imaging in order to study mechanistic role of thrombo-inflammation in the modulation of acute ischemic stroke and thrombosis.  Research projects use molecular and cellular techniques, combined with genetically modified mice to investigate the role of novel molecules in the pathophysiology of atherosclerosis and neointimal hyperplasia.

In addition, my laboratory is part of multi-center Stroke Preclinical Assessment Network ( to test novel cerebroprotective drugs funded by NINDS.


Middle Cerebral Artery Model for Acute Ischemic Stroke in Mice

Middle Cerebral Artery Model for Acute Ischemic Stroke in Mice

Dhanesha et al Blood 2021

Arterial Thrombosis Models in Mice

Nayak Blood 2

Laser-Speckel Imaging after Acute Ischemic Stroke in Mice

Reperfusion image

Mouse model to study Atherosclerosis Progression