The Chauhan Lab explores the molecular and metabolic pathways that govern platelet and leukocyte functions, with the goal of understanding the mechanisms that drive arterial thrombosis, venous thrombosis, and stroke. By uncovering how metabolic enzymes regulate thromboinflammatory responses, our research aims to reveal novel therapeutic targets that may help prevent life-threatening vascular events.

Our approach integrates cutting-edge tools and multidisciplinary strategies to map the cellular and metabolic networks underlying vascular disease:

• high‑resolution in vivo imaging, including intravital microscopy, laser‑speckle contrast imaging, and magnetic resonance imaging,
• genetically engineered models that enable precise dissection of cell-specific metabolic and immune interactions,
• comprehensive molecular and metabolic profiling to identify key signaling pathways regulating platelet and leukocyte function.

The lab is an active partner in the Stroke Preclinical Assessment Network (SPAN), a rigorous multicenter initiative dedicated to advancing and validating new cerebroprotective interventions. Through SPAN, we strengthen the translational impact, reproducibility, and clinical relevance of our discoveries.