Chauhan Lab

Research in my laboratory is focused to better understand how metabolic reprogramming regulates platelet and leukocyte function and whether targeting enzymes involved in aerobic glycolysis can inhibit thrombo-inflammation. If successful, this could be developed as a therapeutic strategy toward better management of patients at high risk for acute coronary events and stroke. We utilize state-of-the-art imaging techniques like intravital microscopy, laser-speckle imaging and magnetic resonance imaging in order to study mechanistic role of thrombo-inflammation in the modulation of acute ischemic stroke and thrombosis. In addition, research projects use molecular and cellular techniques, combined with genetically modified mice to investigate the role of novel molecules in the pathophysiology of atherosclerosis.

In addition, my laboratory is part of multi-center Stroke Preclinical Assessment Network (https://chauhan.lab.uiowa.edu/span) to test novel cerebroprotective drugs funded by NINDS.

Learn more about our research.

Recent News

Dr. Manasa Nayak receives Elaine W. Raines Early Career Investigator Award as a Finalist at Scientific Sessions 2023 (November, 2023)

NIH News: Researchers develop new method to identify potential stroke therapies (September, 2023)

Dr. Mariia Kumskova receives a 2023 ATVB Vascular Discovery Travel Grant for Early Career Investigators (April 2023)

UI team contributes uric acid treatment as a winning approach for improving stroke therapy within the Stroke Pre-Clinical Assessment Network (SPAN) study (March 2023)

Congratulations to IOWA-SPAN Team! Final Result: Uric acid (16mg/kg) given intravenously at the time of reperfusion was found to be cerebroprotective in a multi-center pre-clinical trial (SPAN) (February 2023)

Dr. Rakesh Patel receives a 2023 ISC Junior Investigator Travel Award (November 2022)

See all our lab news.