Research in my laboratory is focused to better understand how metabolic reprogramming regulates platelet and leukocyte function and whether targeting enzymes involved in aerobic glycolysis can inhibit thrombo-inflammation. If successful, this could be developed as a therapeutic strategy toward better management of patients at high risk for acute coronary events and stroke. We utilize state-of-the-art imaging techniques like intravital microscopy, laser-speckle imaging and magnetic resonance imaging in order to study mechanistic role of thrombo-inflammation in the modulation of acute ischemic stroke and thrombosis. In addition, research projects use molecular and cellular techniques, combined with genetically modified mice to investigate the role of novel molecules in the pathophysiology of atherosclerosis and neointimal hyperplasia.
Learn more about our research.
Dr. Mariia Kumskova receives a 2023 ATVB Vascular Discovery Travel Grant for Early Career Investigators (April 2023)
UI team contributes uric acid treatment as a winning approach for improving stroke therapy within the Stroke Pre-Clinical Assessment Network (SPAN) study (March 2023)
Congratulations to IOWA-SPAN Team! Final Result: Uric acid (16mg/kg) given intravenously at the time of reperfusion was found to be cerebroprotective in a multi-center pre-clinical trial (SPAN) (February 2023)
Dr. Rakesh Patel receives a 2023 ISC Junior Investigator Travel Award (November 2022)
Dr. Manasa Nayak receives a 2022 ATVB Scientific Sessions Travel Grant for Early Career Investigators (September 2022)
Dr. Madan Ghatge receives a 2022 THSNA Young Investigator Travel Award (August 2022)
Dr. Gagan D. Flora receives a 2022 GRS Travel Award (July 2022)
Dr. Anil K. Chauhan is named Director of Thrombosis and Vascular Biology (June 2022)
Dr. Manasa Nayak receives an AHA career development award (March 2022)
Dr. Anil K. Chauhan is named to Distinguished Scholar Program (February 2022)